StoppingPatientsNearDose

StoppingPatientsNearDose is the class for stopping based on number of patients near to next best dose.

Usage

StoppingPatientsNearDose(
  nPatients = 10L,
  percentage = 50,
  include_backfill = TRUE,
  report_label = NA_character_
)

.DefaultStoppingPatientsNearDose()

Arguments

nPatients

(number)
see slot definition.

percentage

(number)
see slot definition.

include_backfill

(flag)
see slot definition.

report_label

(string or NA)
see slot definition.

Slots

nPatients

(number)
number of required patients.

percentage

(number)
percentage (between and including 0 and 100) within the next best dose the patients must lie.

include_backfill

(flag)
whether to include backfill patients.

Note

Typically, end users will not use the .DefaultStoppingPatientsNearDose() function.

Examples

# As example, here is the rule for stopping the study if at least 9 patients
# were dosed at a dose within (1 +/- 0.2) of the next best dose.

my_stopping <- StoppingPatientsNearDose(
  nPatients = 9,
  percentage = 20
)

# Variant which excludes backfill cohorts.

my_stopping <- StoppingPatientsNearDose(
  nPatients = 9,
  percentage = 20,
  include_backfill = FALSE
)