Irritable Bowel Syndrome Dose Response data with covariates

A subset of the data used by (Biesheuvel and Hothorn, 2002). The data are part of a dose ranging trial on a compound for the treatment of the irritable bowel syndrome with four active treatment arms, corresponding to doses 1,2,3,4 and placebo. Note that the original dose levels have been blinded in this data set for confidentiality. The primary endpoint was a baseline adjusted abdominal pain score with larger values corresponding to a better treatment effect. In total 369 patients completed the study, with nearly balanced allocation across the doses.

Usage

data(IBScovars)

Format

A data frame with 369 observations on the following 2 variables.

gender

a factor specifying the gender

dose

a numeric vector

resp

a numeric vector

Source

Biesheuvel, E. and Hothorn, L. A. (2002). Many-to-one comparisons in stratified designs, Biometrical Journal, 44, 101–116