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Design dose-reponse trials

Mods() getResp() plotMods() plot(<Mods>)
Define dose-response models
guesst()
Calculate guesstimates based on prior knowledge
optContr() plot(<optContr>) plotContr()
Calculate optimal contrasts
optDesign() calcCrit() rndDesign() plot(<DRdesign>)
Function to calculate optimal designs
planMod() summary(<planMod>) plot(<planMod>)
Evaluate performance metrics for fitting dose-response models
powMCT()
Calculate power for multiple contrast test
sampSize() sampSizeMCT() targN() powN() plot(<targN>)
Sample size calculations
DesignMCPModApp()
Start externally hosted DesignMCPMod Shiny App

Analyze dose-response trials

MCPMod() predict(<MCPMod>) plot(<MCPMod>)
MCPMod - Multiple Comparisons and Modeling
MCTpval()
Calculate multiplicity adjusted p-values for multiple contrast test
MCTtest()
Performs multiple contrast test
bMCTtest()
Performs Bayesian multiple contrast test
powMCTInterim()
Calculate Conditional or Predictive Power for Multiple Contrast Test
critVal()
Calculate critical value for multiple contrast test
mvpostmix()
Prior to posterior updating for a multivariate normal mixture
mvtnorm.control()
Control options for pmvt and qmvt functions

Fit dose-response model

bFitMod() coef(<bFitMod>) predict(<bFitMod>) plot(<bFitMod>)
Fit a dose-response model using Bayesian or bootstrap methods.
defBnds()
Calculates default bounds for non-linear parameters in dose-response models
emax() emaxGrad() sigEmax() sigEmaxGrad() exponential() exponentialGrad() quadratic() quadraticGrad() betaMod() betaModGrad() linear() linearGrad() linlog() linlogGrad() logistic() logisticGrad() linInt() linIntGrad()
Built-in dose-response models in DoseFinding
fitMod() coef(<DRMod>) vcov(<DRMod>) predict(<DRMod>) plot(<DRMod>) logLik(<DRMod>) AIC(<DRMod>) gAIC(<DRMod>)
Fit non-linear dose-response model
maFitMod() predict(<maFit>) plot(<maFit>)
Fit dose-response models via bootstrap model averaging (bagging)
TD() ED()
Calculate dose estimates for a fitted dose-response model (via fitMod, bFitMod) or maFitMod) or a Mods object

Datasets

biom
Biometrics Dose Response data
glycobrom
Glycopyrronium Bromide dose-response data
IBScovars
Irritable Bowel Syndrome Dose Response data with covariates
migraine
Migraine Dose Response data
neurodeg
Neurodegenerative disease simulated longitudinal dose-finding data set