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Design dose-reponse trials

Mods() getResp() plotMods() plot(<Mods>)
Define dose-response models
guesst()
Calculate guesstimates based on prior knowledge
optContr() plot(<optContr>) plotContr()
Calculate optimal contrasts
optDesign() calcCrit() rndDesign() plot(<DRdesign>)
Function to calculate optimal designs
planMod() summary(<planMod>) plot(<planMod>)
Evaluate performance metrics for fitting dose-response models
powMCT()
Calculate power for multiple contrast test
sampSize() sampSizeMCT() targN() powN() plot(<targN>)
Sample size calculations
DesignMCPModApp()
Start externally hosted DesignMCPMod Shiny App

Analyze dose-response trials

MCPMod() predict(<MCPMod>) plot(<MCPMod>)
MCPMod - Multiple Comparisons and Modeling
MCTpval()
Calculate multiplicity adjusted p-values for multiple contrast test
MCTtest()
Performs multiple contrast test
bMCTtest()
Performs Bayesian multiple contrast test
critVal()
Calculate critical value for multiple contrast test
mvpostmix()
Prior to posterior updating for a multivariate normal mixture
mvtnorm.control()
Control options for pmvt and qmvt functions

Fit dose-response model

bFitMod() coef(<bFitMod>) predict(<bFitMod>) plot(<bFitMod>)
Fit a dose-response model using Bayesian or bootstrap methods.
defBnds()
Calculates default bounds for non-linear parameters in dose-response models
emax() emaxGrad() sigEmax() sigEmaxGrad() exponential() exponentialGrad() quadratic() quadraticGrad() betaMod() betaModGrad() linear() linearGrad() linlog() linlogGrad() logistic() logisticGrad() linInt() linIntGrad()
Built-in dose-response models in DoseFinding
fitMod() coef(<DRMod>) vcov(<DRMod>) predict(<DRMod>) plot(<DRMod>) logLik(<DRMod>) AIC(<DRMod>) gAIC(<DRMod>)
Fit non-linear dose-response model
TD() ED()
Calculate dose estimates for a fitted dose-response model (via fitMod or bFitMod) or a Mods object

Datasets

biom
Biometrics Dose Response data
glycobrom
Glycopyrronium Bromide dose-response data
IBScovars
Irritable Bowel Syndrome Dose Response data with covariates
migraine
Migraine Dose Response data
neurodeg
Neurodegenerative disease simulated longitudinal dose-finding data set