Data

Data is a class for the data input. It inherits from GeneralData.

Usage

Data(
  x = numeric(),
  y = integer(),
  ID = integer(),
  cohort = integer(),
  doseGrid = numeric(),
  placebo = FALSE,
  ...
)

.DefaultData()

Arguments

x

(numeric)
the doses for the patients.

y

(integer)
the vector of toxicity events (0 or 1). You can also supply numeric vectors, but these will then be converted to integer internally.

ID

(integer)
unique patient IDs. You can also supply numeric vectors, but these will then be converted to integer internally.

cohort

(integer)
the cohort (non-negative sorted) indices. You can also supply numeric vectors, but these will then be converted to integer internally.

doseGrid

(numeric)
all possible doses.

placebo

(flag)
if TRUE the first dose level in the doseGrid is considered as placebo.

...

not used.

Details

The cohort can be missing if and only if placebo is equal to FALSE.

Slots

x

(numeric)
the doses for the patients.

y

(integer)
the vector of toxicity events (0 or 1 integers).

doseGrid

(numeric)
the vector of all possible doses (sorted), i.e. the dose grid.

nGrid

(integer)
number of gridpoints.

xLevel

(integer)
the levels for the doses the patients have been given, w.r.t doseGrid.

placebo

(logical)
if TRUE the first dose level in the doseGridis considered as PLACEBO.

Note

ID and cohort can be missing. Then a message will be issued and the variables will be filled with default IDs and best guesses cohort, i.e. a sorted (in ascending order) sequence of values from {1, 2, ...}.

Typically, end users will not use the .DefaultData() function.

Examples

my_data <- Data(
  x = c(0.1, 0.5, 1.5, 3, 6, 10, 10, 10),
  y = c(0, 0, 0, 0, 0, 0, 1, 0),
  ID = as.integer(1:8),
  cohort = as.integer(c(1, 2, 3, 4, 5, 6, 6, 6)),
  doseGrid = c(
    0.1,
    0.5,
    1.5,
    3,
    6,
    seq(from = 10, to = 80, by = 2)
  )
)
my_data
#> An object of class "Data"
#> Slot "x":
#> [1]  0.1  0.5  1.5  3.0  6.0 10.0 10.0 10.0
#> 
#> Slot "y":
#> [1] 0 0 0 0 0 0 1 0
#> 
#> Slot "doseGrid":
#>  [1]  0.1  0.5  1.5  3.0  6.0 10.0 12.0 14.0 16.0 18.0 20.0 22.0 24.0 26.0 28.0
#> [16] 30.0 32.0 34.0 36.0 38.0 40.0 42.0 44.0 46.0 48.0 50.0 52.0 54.0 56.0 58.0
#> [31] 60.0 62.0 64.0 66.0 68.0 70.0 72.0 74.0 76.0 78.0 80.0
#> 
#> Slot "nGrid":
#> [1] 41
#> 
#> Slot "xLevel":
#> [1] 1 2 3 4 5 6 6 6
#> 
#> Slot "placebo":
#> [1] FALSE
#> 
#> Slot "ID":
#> [1] 1 2 3 4 5 6 7 8
#> 
#> Slot "cohort":
#> [1] 1 2 3 4 5 6 6 6
#> 
#> Slot "nObs":
#> [1] 8
#>