IncrementsRelativeDLT

IncrementsRelativeDLT is the class for increments control based on relative differences in terms of DLTs.

Usage

IncrementsRelativeDLT(intervals, increments)

.DefaultIncrementsRelativeDLT()

Arguments

intervals

(numeric)
see slot definition.

increments

(numeric)
see slot definition.

Slots

intervals

(integer)
a vector with the left bounds of the relevant DLT intervals. For example, intervals = c(0, 1, 3) specifies three intervals (sets of DLTs: first, 0 DLT; second 1 or 2 DLTs; and the third one, at least 3 DLTs. That means, the right bound of the intervals are exclusive to the interval and the last interval goes from the last value to infinity.

increments

(numeric)
a vector of maximum allowable relative increments corresponding to intervals. IT must be of the same length as the length of intervals.

Note

This considers all DLTs across all cohorts observed so far.

Typically, end users will not use the .DefaultIncrementsRelativeDLT() function.

See also

IncrementsRelativeDLTCurrent which only considers the DLTs in the current cohort.

Examples

# This is the example of a rule for:
# maximum doubling the dose if no DLTs were observed in the whole study so far
# or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed so far
# or maximum increasing the dose by 1.22 if 3 or more DLTs were observed so far.
my_increments <- IncrementsRelativeDLT(
  intervals = c(0, 1, 3),
  increments = c(1, 0.33, 0.2)
)