StoppingMTDCV

StoppingMTDCV is a class for stopping rule based on precision of MTD which is calculated as the coefficient of variation (CV) of the MTD. Here, the MTD is defined as the dose that reaches a specific target probability of the occurrence of a DLT.

Usage

StoppingMTDCV(target = 0.3, thresh_cv = 40, report_label = NA_character_)

.DefaultStoppingMTDCV()

Arguments

target

(proportion)
see slot definition.

thresh_cv

(number)
see slot definition.

report_label

(string or NA)
see slot definition.

Slots

target

(proportion)
toxicity target of MTD (except 0 or 1).

thresh_cv

(number)
threshold (percentage > 0) for CV to be considered accurate enough to stop the trial. The stopping occurs when the CV is less than or equal to tresh_cv.

Note

Typically, end users will not use the .DefaultStoppingMTDCV() function.

Examples

# Stopping the study if the MTD estimation is precise enough, i.e. if robust
# coefficient of variation of the MTD is below 40%.
my_stopping <- StoppingMTDCV(target = 0.3, thresh_cv = 40)