StoppingMTDdistribution

StoppingMTDdistribution is the class for stopping based on the posterior distribution of the MTD. It is used for the cases where the stopping occurs when the probability of MTD > thresh * next_dose is greater than or equal to prob, where the next_dose is the recommended next best dose. Here, the MTD is defined as the dose that reaches a specific target probability of the occurrence of a DLT.

Usage

StoppingMTDdistribution(
  target = 0.33,
  thresh = 0.5,
  prob = 0.9,
  report_label = NA_character_
)

.DefaultStoppingMTDdistribution()

Arguments

target

(proportion)
see slot definition.

thresh

(proportion)
see slot definition.

prob

(proportion)
see slot definition.

report_label

(string or NA)
see slot definition.

Slots

target

(proportion)
the target toxicity probability (except 0 or 1) defining the MTD.

thresh

(proportion)
the threshold (except 0 or 1) relative to the recommended next best dose.

prob

(proportion)
required minimum probability, except 0 or 1.

Note

Typically, end users will not use the .DefaultStoppingMTDDistribution() function.

Examples

# As example, here is the rule for stopping the study if there is at least 0.9
# probability that MTD > 0.5 * next_dose. Here MTD is defined as the dose for
# which prob(DLT) = 0.33
my_stopping <- StoppingMTDdistribution(
  target = 0.33,
  thresh = 0.5,
  prob = 0.9
)