CohortSizeMin

CohortSizeMin is the class for cohort size that is based on minimum of multiple cohort size rules. The cohort_sizes slot stores a set of cohort size rules, which are again the objects of class CohortSize. The minimum of these individual cohort sizes is taken to give the final cohort size.

Usage

CohortSizeMin(cohort_sizes)

.DefaultCohortSizeMin()

Arguments

cohort_sizes

(list)
see slot definition.

Slots

cohort_sizes

(list)
a list of cohort size rules, i.e. objects of class CohortSize.

Note

Typically, end users will not use the .DefaultCohortSizeMin() function.

Examples

# Rule for cohort of size 1 for doses <30 and cohort of size 3 for doses >=30.
my_size1 <- CohortSizeRange(intervals = c(0, 10), cohort_size = c(1, 3))

# Rule for cohort of size 1 until no DLT were observed and cohort of size 3
# as soon as 1 DLT is observed.
my_size2 <- CohortSizeDLT(intervals = c(0, 1), cohort_size = c(1, 3))

# Cohort size rules of class 'CohortSizeMin' which will then be combined with
# the 'min' operation.
my_size <- CohortSizeMin(cohort_sizes = list(my_size1, my_size2))