![[Stable]](figures/lifecycle-stable.svg)
IncrementsRelativeParts is the class for increments control based on
relative differences in intervals, with special rules for part 1 and
beginning of part 2.
Arguments
- dlt_start
(
count)
see slot definition.- clean_start
(
count)
see slot definition.- ...
Arguments passed on to
IncrementsRelativeintervals(
numeric)
see slot definition.increments(
numeric)
see slot definition.
Details
This class works only in conjunction with DataParts objects. If
part 2 will just be started in the next cohort, then the next maximum dose
will be either dlt_start (e.g. -1) shift of the last part 1 dose in case
of a DLT in part 1, or clean_start shift (e.g. -1) in case of no DLTs in
part 1, given that clean_start <= 0 (see description of clean_start
slot for more details). If part 1 will still be on in the next cohort,
then the next dose level will be the next higher dose level in the
part1Ladder slot of the data object. If part 2 has been started before,
the usual relative increment rules apply, see IncrementsRelative.
Slots
dlt_start(
integer)
a scalar, the dose level increment for starting part 2 in case of at least one DLT event in part 1.clean_start(
integer)
a scalar, the dose level increment for starting part 2 in case of no DLTs in part 1. Ifclean_start <= 0, then the part 1 ladder will be used to find the maximum next dose. Otherwise, the relative increment rules will be applied to find the next maximum dose level.
Note
We require that clean_start >= dlt_start. However, this precondition
is not a prerequisite for any function (except of the class' validation
function) that works with objects of this class. It is rather motivated by
the semantics. That is, if we observe a DLT in part 1, we cannot be more
aggressive than in case of a clean part 1 without DLT.
Typically, end users will not use the .DefaultIncrementsRelativeParts() function.