NextBestMTD — NextBestMTD-class • crmPack

NextBestMTD is the class for next best dose based on MTD estimate.

Usage

NextBestMTD(target, derive)

.DefaultNextBestMTD()

Arguments

target: (proportion)
see slot definition.
derive: (function)
see slot definition.

Slots

target: (proportion)
target toxicity probability, except 0 or 1.
derive: (function)
a function which derives the final next best MTD estimate, based on vector of posterior MTD samples. It must therefore accept one and only one argument, which is a numeric vector, and return a number.

Note

Typically, end users will not use the .DefaultNextBestMTD() function.

Examples

# In the example below, the MTD is defined as the dose for which prob(DLE) = 0.33
# and we will use the 25th quantile of the posterior of MTD as our next best dose.
next_best_mtd <- NextBestMTD(
  target = 0.33,
  derive = function(mtd_samples) {
    quantile(mtd_samples, probs = 0.25)
  }
)