PseudoSimulations

This class captures trial simulations from designs using pseudo model. It has additional slots fit and stop_reasons compared to the general class GeneralSimulations.

Usage

PseudoSimulations(
  fit,
  final_td_target_during_trial_estimates,
  final_td_target_end_of_trial_estimates,
  final_td_target_during_trial_at_dose_grid,
  final_td_target_end_of_trial_at_dose_grid,
  final_tdeot_cis,
  final_tdeot_ratios,
  final_cis,
  final_ratios,
  stop_report,
  stop_reasons,
  ...
)

.DefaultPseudoSimulations()

Arguments

fit

(list)
see slot definition.

final_td_target_during_trial_estimates

(numeric)
see slot definition.

final_td_target_end_of_trial_estimates

(numeric)
see slot definition.

final_td_target_during_trial_at_dose_grid

(numeric)
see slot definition.

final_td_target_end_of_trial_at_dose_grid

(numeric)
see slot definition.

final_tdeot_cis

(list)
see slot definition.

final_tdeot_ratios

(numeric)
see slot definition.

final_cis

(list)
see slot definition.

final_ratios

(numeric)
see slot definition.

stop_report

see PseudoSimulations

stop_reasons

(list)
see slot definition.

...

additional parameters from GeneralSimulations

Slots

fit

(list)
final fit values.

final_td_target_during_trial_estimates

(numeric)
final estimates of the td_target_during_trial.

final_td_target_end_of_trial_estimates

(numeric)
final estimates of the td_target_end_of_trial.

final_td_target_during_trial_at_dose_grid

(numeric)
dose levels at dose grid closest below the final td_target_during_trial estimates.

final_td_target_end_of_trial_at_dose_grid

(numeric)
dose levels at dose grid closest below the final td_target_end_of_trial estimates.

final_tdeot_cis

(list)
95% credibility intervals of the final estimates for td_target_end_of_trial.

final_tdeot_ratios

(numeric)
ratio of the upper to the lower 95% credibility intervals for td_target_end_of_trial.

final_cis

(list)
final 95% credibility intervals for td_target_end_of_trial estimates.

final_ratios

(numeric)
final ratios of the upper to the lower 95% credibility interval for td_target_end_of_trial.

stop_report

(matrix)
outcomes of stopping rules.

stop_reasons

(list)
reasons for stopping each simulation run.

Note

Typically, end users will not use the .DefaultPseudoSimulations() function.