StoppingTargetBiomarker

StoppingTargetBiomarker is a class for stopping based on probability of target biomarker.

Usage

StoppingTargetBiomarker(
  target = c(0.9, 1),
  prob = 0.3,
  is_relative = TRUE,
  report_label = NA_character_
)

.DefaultStoppingTargetBiomarker()

Arguments

target

(numeric)
see slot definition.

prob

(proportion)
see slot definition.

is_relative

(flag)
see slot definition.

report_label

(string or NA)
see slot definition.

Slots

target

(numeric)
the biomarker target range that needs to be reached. For example, target = c(0.8, 1.0) with is_relative = TRUE means that we target a dose with at least 80% of maximum biomarker level.

is_relative

(flag)
is target relative? If it so (default), then the target is interpreted relative to the maximum, so it must be a probability range. Otherwise, the target is interpreted as absolute biomarker range.

prob

(proportion)
required target probability (except 0 or 1) for reaching sufficient precision.

Note

Typically, end users will not use the .DefaultStoppingTargetBiomarker() function.

Examples

# Stopping the study if there is at least 0.5 probability that the biomarker
# (efficacy) is within the biomarker target range of [0.9, 1.0] (relative to the
# maximum for the biomarker).

my_stopping <- StoppingTargetBiomarker(target = c(0.9, 1), prob = 0.5)