Updating Data Objects

A method that updates existing Data object with new data.

Usage

# S4 method for Data
update(
  object,
  x,
  y,
  ID = length(object@ID) + seq_along(y),
  new_cohort = TRUE,
  check = TRUE,
  ...
)

Arguments

object

(Data)
object you want to update.

x

(number)
the dose level (one level only!).

y

(integer)
the DLT vector (0/1 vector) for all patients in this cohort. You can also supply numeric vectors, but these will then be converted to integer internally.

ID

(integer)
the patient IDs. You can also supply numeric vectors, but these will then be converted to integer internally.

new_cohort

(flag)
if TRUE (default) the new data are assigned to a new cohort.

check

(flag)
whether the validation of the updated object should be conducted. See details below.

...

not used.

Value

The new, updated Data object.

Details

The current implementation of this update method allows for updating the Data class object by adding a single dose level x only. However, there might be some use cases where the new cohort to be added contains a placebo and active dose. Hence, such update would need to be performed iteratively by calling the update method twice. For example, in the first call a user can add a placebo, and then in the second call, an active dose. Since having a cohort with placebo only is not allowed, the update method would normally throw the error when attempting to add a placebo in the first call. To allow for such updates, the check parameter should be then set to FALSE for that first call.

Examples

# Create some data of class 'Data'.
my_data <- Data(
  x = c(0.1, 0.5, 1.5, 3, 6, 10, 10, 10),
  y = c(0, 0, 0, 0, 0, 0, 1, 0),
  doseGrid = c(0.1, 0.5, 1.5, 3, 6, seq(from = 10, to = 80, by = 2))
)
#> Used default patient IDs!
#> Used best guess cohort indices!

# Update the data with a new cohort.
my_data1 <- update(my_data, x = 20, y = c(0L, 1L, 1L))
my_data1
#> An object of class "Data"
#> Slot "x":
#>  [1]  0.1  0.5  1.5  3.0  6.0 10.0 10.0 10.0 20.0 20.0 20.0
#> 
#> Slot "y":
#>  [1] 0 0 0 0 0 0 1 0 0 1 1
#> 
#> Slot "doseGrid":
#>  [1]  0.1  0.5  1.5  3.0  6.0 10.0 12.0 14.0 16.0 18.0 20.0 22.0 24.0 26.0 28.0
#> [16] 30.0 32.0 34.0 36.0 38.0 40.0 42.0 44.0 46.0 48.0 50.0 52.0 54.0 56.0 58.0
#> [31] 60.0 62.0 64.0 66.0 68.0 70.0 72.0 74.0 76.0 78.0 80.0
#> 
#> Slot "nGrid":
#> [1] 41
#> 
#> Slot "xLevel":
#>  [1]  1  2  3  4  5  6  6  6 11 11 11
#> 
#> Slot "placebo":
#> [1] FALSE
#> 
#> Slot "ID":
#>  [1]  1  2  3  4  5  6  7  8  9 10 11
#> 
#> Slot "cohort":
#>  [1] 1 2 3 4 5 6 6 6 7 7 7
#> 
#> Slot "nObs":
#> [1] 11
#>