Updating DataDA Objects

A method that updates existing DataDA object with new data.

Usage

# S4 method for class 'DataDA'
update(object, u, t0, trialtime, y, ..., check = TRUE)

Arguments

object

(DataDA)
object you want to update.

u

(numeric)
the new DLT free survival times for all patients, i.e. for existing patients in the object as well as for new patients.

t0

(numeric)
the time that each patient starts DLT observation window. This parameter covers all patients, i.e. existing patients in the object as well as for new patients.

trialtime

(number)
current time in the trial, i.e. a followup time.

y

(numeric)
the new DLTs for all patients, i.e. for existing patients in the object as well as for new patients.

...

further arguments passed to Data update method update-Data. These are used when there are new patients to be added to the cohort.

check

(flag)
whether the validation of the updated object should be conducted. See help for update-Data for more details on the use case of this parameter.

Value

The new, updated DataDA object.

Note

This function is capable of not only adding new patients but also updates existing ones with respect to y, t0, u slots.

Examples

# Create an object of class 'DataDA'.
my_data <- DataDA(
  x = c(0.1, 0.5, 1.5, 3, 6, 10, 10, 10),
  y = c(0, 0, 1, 1, 0, 0, 1, 0),
  doseGrid = c(0.1, 0.5, 1.5, 3, 6, seq(from = 10, to = 80, by = 2)),
  u = c(42, 30, 15, 5, 20, 25, 30, 60),
  t0 = c(0, 15, 30, 40, 55, 70, 75, 85),
  Tmax = 60
)
#> Used default patient IDs!
#> Used best guess cohort indices!

# Update the data.
my_data1 <- update(
  object = my_data,
  y = c(my_data@y, 0), # The 'y' will be updated according to 'u'.
  u = c(my_data@u, 20),
  t0 = c(my_data@t0, 95),
  x = 20,
  trialtime = 120 # This is the global timeline for a trial.
)
my_data1
#> An object of class "DataDA"
#> Slot "u":
#> [1] 42 30 15  5 20 25 30 35 20
#> 
#> Slot "t0":
#> [1]  0 15 30 40 55 70 75 85 95
#> 
#> Slot "Tmax":
#> [1] 60
#> 
#> Slot "x":
#> [1]  0.1  0.5  1.5  3.0  6.0 10.0 10.0 10.0 20.0
#> 
#> Slot "y":
#> [1] 0 0 1 1 0 0 1 0 0
#> 
#> Slot "doseGrid":
#>  [1]  0.1  0.5  1.5  3.0  6.0 10.0 12.0 14.0 16.0 18.0 20.0 22.0 24.0 26.0 28.0
#> [16] 30.0 32.0 34.0 36.0 38.0 40.0 42.0 44.0 46.0 48.0 50.0 52.0 54.0 56.0 58.0
#> [31] 60.0 62.0 64.0 66.0 68.0 70.0 72.0 74.0 76.0 78.0 80.0
#> 
#> Slot "nGrid":
#> [1] 41
#> 
#> Slot "xLevel":
#> [1]  1  2  3  4  5  6  6  6 11
#> 
#> Slot "placebo":
#> [1] FALSE
#> 
#> Slot "ID":
#> [1] 1 2 3 4 5 6 7 8 9
#> 
#> Slot "cohort":
#> [1] 1 2 3 4 5 6 6 6 7
#> 
#> Slot "nObs":
#> [1] 9
#>