RuleDesignOrdinal

RuleDesignOrdinal is the class for rule-based designs. The difference between this class and the DesignOrdinal class is that RuleDesignOrdinal does not contain model, stopping and increments slots.

Usage

RuleDesignOrdinal(next_best, cohort_size, data, starting_dose)

.DefaultRuleDesignOrdinal()

Arguments

next_best

(NextBestOrdinal)
see slot definition.

cohort_size

(CohortSizeOrdinal)
see slot definition.

data

(DataOrdinal)
see slot definition.

starting_dose

(number)
see slot definition.

Slots

next_best

(NextBestOrdinal)
how to find the next best dose.

cohort_size

(CohortSizeOrdinal)
rules for the cohort sizes.

data

(DataOrdinal)
specifies dose grid, any previous data, etc.

starting_dose

(number)
the starting dose, it must lie on the dose grid in data.

Note

Typically, end users will not use the .DefaultRuleDesignOrdinal() function.

Examples

RuleDesignOrdinal(
  next_best = NextBestOrdinal(
    1L,
    NextBestMTD(
      target = 0.25,
      derive = function(x) median(x, na.rm = TRUE)
    )
  ),
  cohort_size = CohortSizeOrdinal(1L, CohortSizeConst(size = 3L)),
  data = DataOrdinal(doseGrid = c(5, 10, 15, 25, 35, 50, 80)),
  starting_dose = 5
)
#> An object of class "RuleDesignOrdinal"
#> Slot "next_best":
#> An object of class "NextBestOrdinal"
#> Slot "grade":
#> [1] 1
#> 
#> Slot "rule":
#> An object of class "NextBestMTD"
#> Slot "target":
#> [1] 0.25
#> 
#> Slot "derive":
#> function (x) 
#> median(x, na.rm = TRUE)
#> <environment: 0x55c95ab5f550>
#> 
#> 
#> 
#> Slot "cohort_size":
#> An object of class "CohortSizeOrdinal"
#> Slot "grade":
#> [1] 1
#> 
#> Slot "rule":
#> An object of class "CohortSizeConst"
#> Slot "size":
#> [1] 3
#> 
#> 
#> 
#> Slot "data":
#> An object of class "DataOrdinal"
#> Slot "x":
#> numeric(0)
#> 
#> Slot "y":
#> integer(0)
#> 
#> Slot "doseGrid":
#> [1]  5 10 15 25 35 50 80
#> 
#> Slot "nGrid":
#> [1] 7
#> 
#> Slot "xLevel":
#> integer(0)
#> 
#> Slot "yCategories":
#> No DLT    DLT 
#>      0      1 
#> 
#> Slot "placebo":
#> [1] FALSE
#> 
#> Slot "ID":
#> integer(0)
#> 
#> Slot "cohort":
#> integer(0)
#> 
#> Slot "nObs":
#> [1] 0
#> 
#> 
#> Slot "starting_dose":
#> [1] 5
#>