Get Closest Grid Doses for a Given Target Doses for nextBest-NextBestMaxGain Method.

Helper function that for a given target doses finds the dose in grid that is closest and below the target. There are four different targets in the context of nextBest-NextBestMaxGain() method: \(min(`dose_mg`, `dose_target_drt`)\), dose_mg, dose_target_drt or dose_target_eot.

Usage

h_next_best_mg_doses_at_grid(
  dose_target_drt,
  dose_target_eot,
  dose_mg,
  dose_grid,
  doselimit,
  placebo
)

Arguments

dose_target_drt

(number)
target dose estimate during the trial.

dose_target_eot

(number)
target dose estimate at the end of the trial.

dose_mg

(number)
the dose corresponding to the maximum gain.

dose_grid

(numeric)
all possible doses.

doselimit

(number)
the maximum allowed next dose.

placebo

(flag)
if TRUE the first dose level in the dose_grid is considered as placebo.