S3 Interface

simaerep()

create simaerep object

plot(<simaerep>)

plot AE under-reporting simulation results

Main Functions

site_aggr()

Aggregate from visit to site level.

sim_sites()

Calculate prob_lower and poisson.test pvalue for study sites.

eval_sites()

Evaluate sites.

plot_study()

Plot ae development of study and sites highlighting at risk sites.

check_df_visit()

Integrity check for df_visit.

Simulate Data

sim_test_data_study()

simulate study test data

get_config()

Get Portfolio Configuration

sim_test_data_portfolio()

Simulate Portfolio Test Data

Test Functions

These functions are intented to check simaerep performance.

sim_studies()

Simulate studies.

sim_ur_scenarios()

Simulate Under-Reporting Scenarios

get_portf_perf()

Get Portfolio Performance

Helper Functions

These functions are intended to be called by other functions.

get_pat_pool_config()

Configure study patient pool by site parameters.

pat_pool()

Create a study specific patient pool for sampling

poiss_test_site_ae_vs_study_ae()

Poisson test for vector with site AEs vs vector with study AEs.

prob_lower_site_ae_vs_study_ae()

Calculate bootstrapped probability for obtaining a lower site mean AE number.

sim_test_data_patient()

simulate patient ae reporting test data

get_visit_med75()

Get visit_med75.

pat_aggr()

Aggregate visit to patient level.

get_site_mean_ae_dev()

Get site mean ae development.

aggr_duplicated_visits()

Aggregate duplicated visits.

exp_implicit_missing_visits()

Expose implicitly missing visits.

prep_for_sim()

Prepare data for simulation.

sim_after_prep()

Start simulation after preparation.

get_ecd_values()

Get empirical cumulative distribution values of pval or prob_lower

purrr_bar()

Execute a purrr or furrr function with a progress bar.

with_progress_cnd()

Conditional with_progress.

sim_scenario()

simulate single scenario

orivisit()

create orivisit object

is_simaerep()

is simaerep class

is_orivisit()

is orivisit class

Deprecated

eval_sites_deprecated()

Evaluate sites.

Additional Plot Functions

These functions are intended for creating plots for the documentation.

plot_visit_med75()

Plot patient visits against visit_med75.

plot_sim_examples()

Plot multiple simulation examples.

plot_sim_example()

Plot simulation example.

plot_dots()

Plots AE per site as dots.