Package index • simaerep

S3 Interface

simaerep(): Create simaerep object

plot(<simaerep>): plot AE under-reporting simulation results

Main Functions

site_aggr(): Aggregate from visit to site level.

sim_sites(): Calculate prob_lower and poisson.test pvalue for study sites.

sim_inframe(): Calculate prob_lower for study sites using table operations

eval_sites(): Evaluate sites.

prune_to_visit_med75_inframe(): prune visits to visit_med75 using table operations

plot_study(): Plot ae development of study and sites highlighting at risk sites.

check_df_visit(): Integrity check for df_visit.

Simulate Data

sim_test_data_study(): simulate study test data

get_config(): Get Portfolio Configuration

sim_test_data_portfolio(): Simulate Portfolio Test Data

Test Functions

These functions are intented to check simaerep performance.

sim_studies(): Simulate studies.

sim_ur_scenarios(): Simulate Under-Reporting Scenarios

sim_ur(): simulate under-reporting

get_portf_perf(): Get Portfolio Performance

Helper Functions

These functions are intended to be called by other functions.

get_pat_pool_config(): Configure study patient pool by site parameters.

pat_pool(): Create a study specific patient pool for sampling

poiss_test_site_ae_vs_study_ae(): Poisson test for vector with site AEs vs vector with study AEs.

prob_lower_site_ae_vs_study_ae(): Calculate bootstrapped probability for obtaining a lower site mean AE number.

sim_test_data_patient(): simulate patient ae reporting test data

get_visit_med75(): Get visit_med75.

pat_aggr(): Aggregate visit to patient level.

get_site_mean_ae_dev(): Get site mean ae development.

aggr_duplicated_visits(): Aggregate duplicated visits.

exp_implicit_missing_visits(): Expose implicitly missing visits.

prep_for_sim(): Prepare data for simulation.

sim_after_prep(): Start simulation after preparation.

get_ecd_values(): Get empirical cumulative distribution values of pval or prob_lower

purrr_bar(): Execute a purrr or furrr function with a progress bar.

with_progress_cnd(): Conditional with_progress.

sim_scenario(): simulate single scenario

orivisit(): create orivisit object

is_simaerep(): is simaerep class

is_orivisit(): is orivisit class

max_rank(): Calculate Max Rank

Additional Plot Functions

These functions are intended for creating plots for the documentation.

plot_visit_med75(): Plot patient visits against visit_med75.

plot_sim_examples(): Plot multiple simulation examples.

plot_sim_example(): Plot simulation example.

plot_dots(): Plots AE per site as dots.